No Gene Mutation Found: Next Steps for Your Mental Health

Could Hormones and Gene Mutations Be Connected?

Although no gene mutations were identified in your results, it’s worth noting that certain mutations can affect how your body processes and responds to hormones like dopamine, cortisol, and serotonin. Understanding these potential gene-hormone interactions can provide deeper insights into mental health challenges.

COMT (Catechol-O-methyltransferase) Gene Mutation affects dopamine breakdown, influencing mood and stress responses. Variations in this gene can impact how your body handles dopamine levels, potentially contributing to mood swings and stress. Genetic testing specifically targeting the COMT gene can reveal variations, such as the Val158Met polymorphism. This test can show whether an individual has a slower or faster COMT enzyme activity, influencing dopamine levels.

MTHFR (Methylenetetrahydrofolate reductase) Gene Mutation plays a role in methylation, which can affect cortisol regulation. Mutations here may impair your ability to manage stress, leading to higher cortisol levels and associated anxiety or fatigue. Genetic testing can detect common MTHFR gene mutations, such as C677T and A1298C. These mutations affect methylation efficiency and folate metabolism, impacting overall health and mood regulation.

SLC6A4 (Serotonin Transporter) Gene Mutation regulates serotonin reuptake. Mutations in this gene can alter serotonin levels, influencing mood stability and susceptibility to depression or anxiety. Testing for the SLC6A4 gene can identify the presence of variations, such as the short (S) and long (L) alleles. 

MAOA (Monoamine Oxidase A) Gene Mutation is involved in breaking down neurotransmitters like norepinephrine, serotonin and dopamine. Variations can lead to imbalances that affect mood and stress sensitivity. Genetic tests can identify variations in the MAOA gene, such as the MAOA-L (low activity) variant, which is linked to increased aggression, anxiety and mood disorders.

OPRM1 (Mu-Opioid Receptor) Gene Mutation influences how endorphins bind to their receptors, affecting pain relief and mood regulation. Gene mutations here may result in a reduced ability to manage pain and stress. Genetic testing can reveal mutations in the OPRM1 gene, such as the A118G polymorphism, which affects how the body responds to endorphins and opioids, influencing pain sensitivity and mood regulation.

OXTR (Oxytocin Receptor) Gene Mutation impacts social bonding and emotional regulation. Mutations in this gene can affect how you experience trust and social interactions, influencing overall emotional well-being. Testing for the OXTR gene can uncover variations that influence how oxytocin interacts with its receptors, impacting social behavior, trust and emotional regulation.

ADRB2 (Beta-2 Adrenergic Receptor) Gene Mutation affects the body’s response to adrenaline. Genetic tests can detect mutations in the ADRB2 gene, which can affect the body’s response to adrenaline, influencing stress responses and energy levels.

While your test did not identify specific gene mutations, these connections illustrate how genetic factors can potentially influence hormone levels and contribute to mental health challenges. Exploring these interactions further with a healthcare professional may provide additional insights into understanding and managing your well-being.